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Topical Retinoids

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Skin Care

By Dr. Gözde Coşar Seyhan
OnOctober 13, 2022
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Topical Retinoids are Vitamin A derivatives.

 

How do they work?

  • They are effective in both the superficial (epidermis) and deep (dermis) layers of the skin.
  • They clean the dead cells on the epidermis through exfoliation, preventing clogged pores, blackheads, and acne formation.
  • They trigger collagen and elastin production in the dermis, improving the appearance of wrinkles.
  • They are anti-aging agents that combat the DNA damage caused by UV radiation.
  • As skin cells renew, they contribute to gradual improvement in pigmentation.

 

How to use?

  • Available in forms like creams, gels, serums, with different concentrations.
  • Prescription forms include tretinoin, tazarotene, adapalene, while cosmetic products contain retinol, retinyl esters, retinaldehyde.
  • Active forms are Retinyl esters, retinol, retinaldehyde, and tretinoin.
  • Preceding exfoliation can enhance the penetration of retinoids, but not suitable for combined use on all skin types.
  • Healing effect on acne can be observed after at least 1 month, while rejuvenating (anti-aging) effect takes a minimum of 3 months of usage.

 

Points to consider!

  • Retinoids do not work the same for everyone; some skin types may not tolerate them.
  • Common side effects include redness, burning, itching, and dryness. Gradual usage and avoiding excessive application are important when introducing retinoids to your skin (low concentration, twice a week, and short waiting times).
  • Increases sensitivity to sunlight. Applying at night and using SPF during the day is necessary.
  • Not suitable for use during pregnancy and breastfeeding.

 

How to incorporate Retinoids into skincare?

1. Skin acclimatization method – once a week with a minimal dose.

2. Sandwich technique – moisturizer – retinoid – moisturizer.

 

About Retinyl Esters…

Retinyl palmitate and retinyl acetate

These topical retinoid forms are not sufficiently effective for anti-aging purposes.

Instead, use these agents:

 

  • Retinol
  • Retinaldehyde
  • Adapalene
  • Tretinoin
  • Tazarotene
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